GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UVM | cis | rs4294134 | 1 | rs10234309 | chr7:135311167 | PL-5283 | chr7:135347221-135378160:+ | 0.69 | 5.84 | 2.88E-7 | Paget's disease |
| UVM | cis | rs8078723 | 1 | rs1042658 | chr17:38173902 | GSDMA | chr17:38119226-38134019:+ | -0.87 | -7.55 | 4.73E-10 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| UVM | cis | rs703842 | 1 | rs10431505 | chr12:58178589 | TSFM | chr12:58176536-58191367:+ | -0.57 | -5.04 | 5.32E-6 | Multiple sclerosis |
| UVM | cis | rs4660306 | 1 | rs1044717 | chr1:45976587 | CCDC163P | chr1:45960581-45965646:- | -0.83 | -9.05 | 1.73E-12 | Homocysteine levels |
| UVM | cis | rs10461617 | 1 | rs10461617 | chr5:56104308 | C5orf35 | chr5:56205103-56213010:+ | 0.95 | 6.34 | 4.59E-8 | Type 2 diabetes |
| UVM | cis | rs1046896 | 1 | rs1046875 | chr17:80685426 | FN3KRP | chr17:80674582-80685889:+ | 0.56 | 5.41 | 1.4E-6 | Glycated hemoglobin levels |
| UVM | cis | rs1046896 | 1 | rs1046896 | chr17:80685533 | FN3KRP | chr17:80674582-80685889:+ | 0.56 | 5.41 | 1.4E-6 | Glycated hemoglobin levels |
| UVM | cis | rs1046896 | 1 | rs1046917 | chr17:80685655 | FN3KRP | chr17:80674582-80685889:+ | 0.56 | 5.41 | 1.4E-6 | Glycated hemoglobin levels |
| UVM | cis | rs9876781 | 1 | rs10470686 | chr3:48449956 | TREX1 | chr3:48501186-48509043:+ | -0.39 | -5.06 | 5.03E-6 | Longevity |
| UVM | cis | rs11190604 | 1 | rs10509744 | chr10:102271579 | SEC31B | chr10:102246403-102289636:- | -0.39 | -5.03 | 5.66E-6 | Palmitoleic acid (16:1n-7) plasma levels |
| UVM | cis | rs11190604 | 1 | rs1054399 | chr10:102312565 | SEC31B | chr10:102246403-102289636:- | -0.39 | -5.1 | 4.38E-6 | Palmitoleic acid (16:1n-7) plasma levels |
| UVM | cis | rs4660306 | 1 | rs10736426 | chr1:45984353 | CCDC163P | chr1:45960581-45965646:- | 0.79 | 8.63 | 8.44E-12 | Homocysteine levels |
| UVM | cis | rs703842 | 1 | rs10747783 | chr12:58176614 | TSFM | chr12:58176536-58191367:+ | -0.57 | -5.04 | 5.32E-6 | Multiple sclerosis |
| UVM | cis | rs1411478 | 1 | rs10753232 | chr1:180950126 | STX6 | chr1:180913175-180992046:- | 0.58 | 5.62 | 6.56E-7 | Progressive supranuclear palsy |
| UVM | cis | rs2016266 | 1 | rs10783573 | chr12:53728369 | PFDN5 | chr12:53689235-53693232:+ | -0.42 | -5.18 | 3.29E-6 | Bone mineral density;Bone mineral density (spine) |